Peptide YYand leptin Peptide YY (PYY) is a fascinating gut hormone that plays a significant role in regulating appetite and has emerged as a crucial factor in the complex landscape of obesity. Research consistently indicates that alterations in PYY levels are closely linked to body weight regulation, with reduced PYY concentrations often observed in individuals struggling with obesity. This hormonal imbalance can lead to impaired satiety signals, potentially contributing to increased food intake and hindering weight loss efforts.作者：BS Wulff·2025·被引用次数：3—The hormone peptide YY (PYY), particularly its Y2 receptor-selective form PYY3-36,is known to play a role in regulating hunger and satietyand ... Understanding the mechanisms by which PYY influences appetite and its connection to obesity is vital for developing effective strategies to combat this widespread health issue.
Peptide YY is primarily released from specialized cells in the small and large intestines in response to the presence of nutrients, particularly fats and proteins, after a meal. Its primary function is to signal to the brain that the body is full, thereby reducing appetite and promoting satiety. This signaling occurs through its action on specific receptors in the hypothalamus, a region of the brain that controls hunger and fullnessAIMS/HYPOTHESIS:Obese people exhibit reduced circulating peptide YY (PYY) levels, but it is unclear whether this is a consequence or cause of obesity..
One of the most studied forms of PYY is PYY3-36, which is known to effectively reduce food intake and promote feelings of fullness.Peptide YY in Type 2 Diabetes: A Complementary Gut ... When PYY3-36 binds to its receptors, it suppresses appetite-stimulating neuropeptides and enhances the release of satiety-promoting signals. This interplay is critical for maintaining energy balance and preventing overeating.
A consistent finding across numerous studies is that individuals with obesity often exhibit lower circulating levels of PYY, particularly in the fasting state and after a meal (postprandial). This reduction in PYY may contribute to the development and maintenance of obesity by diminishing the body's natural ability to signal fullness.Weight Loss With a Novel Peptide YY Analogue for Obesity Consequently, individuals with insufficient PYY may experience prolonged feelings of hunger and a reduced sense of satisfaction after eating, leading to increased calorie consumptionPYY has been thoroughly examined for its ability to curb appetite in connection, with obesityand metabolic issues. The levels of PYY are often altered in ....
Conversely, studies have shown that interventions leading to weight loss, such as gastric bypass surgery or supplementation with certain fibers, can be associated with increased PYY levels.作者：E Karra·2008·被引用次数：459—Several lines of evidence suggest that low circulatingPYYconcentrations predispose towards the development and or maintenance ofobesity. Subjects with ... This suggests a potential feedback loop where successful weight management can improve PYY secretion, further supporting appetite control and weight maintenance.PYY has been thoroughly examined for its ability to curb appetite in connection, with obesityand metabolic issues. The levels of PYY are often altered in ...
Given its significant role in appetite regulation, PYY and its analogues have garnered considerable attention as potential therapeutic agents for obesity作者：T Tan·2021·被引用次数：1—Gut hormones such as peptide YY (PYY)have emerged as candidate therapies for obesitywhich activate natural satiety pathways, reduce food .... The ability of PYY to reduce food intake and promote satiety makes it an attractive target for developing new weight-loss strategies.
Research is exploring various approaches, including the development of long-acting PYY analogues and combination therapies. For instance, studies have investigated the efficacy of combining PYY analogues with other gut hormones like glucagon-like peptide-1 (GLP-1), which also plays a role in appetite control and glucose regulation. These combination therapies aim to leverage the synergistic effects of multiple hormones to achieve more substantial and sustained weight loss.
While PYY therapy holds promise, further research is needed to fully understand its long-term efficacy, safety, and optimal therapeutic strategies for diverse patient populationsWeight loss during oligofructose supplementation is .... The focus remains on harnessing PYY's natural satiety-promoting mechanisms to help individuals manage their weight effectively.
Several factors can influence the circulating levels of PYY. Beyond meal composition, macronutrient intake, particularly high-protein diets, has been shown to stimulate the release of PYY, contributing to increased satiety作者：M Oertel·2024·被引用次数：12—A combinatory treatment with a non-selectivePYYanalog and semaglutide led to a maximum body weight loss of 14.0 ± 4.9% vs 9.9 ± 1.5% with semaglutide alone.. Dietary fibers, such as oligofructose, have also been linked to increased PYY levels and subsequent weight loss in overweight and obese adults.
Other factors that may affect PYY levels include exercise, adiposity, race, and the composition of dietary fats. Understanding these influences can provide further insights into personalized approaches for optimizing PYY function and supporting weight management.
Peptide YY is a critical gut hormone involved in regulating appetite and plays a significant role in the pathophysiology of obesityResearch and prospect of peptides for use in obesity treatment (Review). Lower circulating levels of PYY are frequently observed in individuals with obesity, potentially contributing to impaired satiety and increased food intake. The growing body of research exploring PYY as a therapeutic target highlights its potential in the fight against obesity, with ongoing investigations into PYY analogues and combination therapies aiming to harness its appetite-suppressing properties for effective weight management. Continued exploration of the intricate relationship between PYY, diet, and obesity promises to yield valuable insights for both clinical practice and public health initiatives.
Join the newsletter to receive news, updates, new products and freebies in your inbox.