peptide-for-hairgrowth The dominant search intent for "vasoactive intestinal peptide antibody" appears to be informational, focusing on understanding what these antibodies are, their applications, and where to find them. The SERP data indicates a strong interest in the properties, target molecule, and usage of these antibodies in research contexts.
Tier 1 Entities and Phrases:
* Vasoactive intestinal peptide antibody (search_keyword)
* Vasoactive intestinal polypeptide (VIP)
* Antibody
* Available from several suppliers
* Monoclonal anti-vasoactive intestinal polypeptide (VIP) antibodies
* Target protein: vasoactive intestinal peptide
Tier 2 Entities and Phrases:
* VIP (Vasoactive Intestinal Peptide) Antibody
* Rabbit Monoclonal Antibody
* IHC Formulated
* Neuropeptide
* Secretin-glucagon family
* Peptide hormone
* 28-amino-acid peptide
* Ganglion cells
* Small bowel
* Human, Mouse, Rat, Mammals
* Myocardial contractility
* Vasodilation
* Glycogenolysis
* Arterial blood pressure
* Smooth muscle of trachea
* Embryonic and adult tissues
* Immunosuppressive properties
* Upregulated in tumors
* ELISA, IHC, ICC, IP, WB
* Rat amygdala, cortex, suprachiasmatic nucleus
* Vasoactive intestinal peptide receptor 1 (VIP-R1)
* Vasoactive intestinal polypeptide receptor 2 (VIP-R2)
Tier 3 Entities and Phrases:
* "For antibodies with volumes of 200 µl or less" (instructional, not core topic)
* "to maintain closure of the proximal end of the esophagus" (specific function, less relevant to antibody itself)
* "causes vasodilation" (function of VIP, not antibody)
* "provides strong fluorescent staining" (application detail)
* "neurons" (target cell type, can be implied)
* "peptides" (general term, VIP is more specific)
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A vasoactive intestinal peptide (VIP) antibody is a crucial tool for researchers investigating the role of VIP, a significant neuropeptide, across various biological systems. These antibodies are designed to specifically bind to vasoactive intestinal polypeptide (VIP), allowing for its detection, localization, and quantification in biological samples. VIP, a 28-amino-acid peptide belonging to the secretin-glucagon family of peptide hormones, plays a diverse range of physiological roles, from neurotransmission and smooth muscle relaxation to immune modulation and cell proliferation. Understanding the properties and applications of VIP antibodies is essential for advancing research in endocrinology, gastroenterology, neuroscience, and beyond.
Vasoactive intestinal peptide (VIP) is a widely distributed peptide hormone found in various tissues, including the central and peripheral nervous systems, gastrointestinal tract, and endocrine glands. It is synthesized as a precursor protein that is processed into the mature 28-residue peptideVasoactive Intestinal Polypeptide (VIP) antibody – Concentrate; Product No · PAB532C ; Unit · 0.2 ml ; SKU PAB532C .... VIP exerts its effects by binding to specific receptors, VIP-R1 and VIP-R2, which are coupled to G proteins and activate adenylyl cyclase, influencing cellular signaling pathwaysVasoactive Intestinal Polypeptide (VIP) antibody – Concentrate; Product No · PAB532C ; Unit · 0.2 ml ; SKU PAB532C .... Its functions are broad, encompassing vasodilation, stimulation of myocardial contractility, regulation of smooth muscle tone in the trachea and gut, and influencing glycogenolysis作者：S Mei·1991·被引用次数：116—This paper describes evidence for hydrolysis of a neuropeptide,vasoactive intestinal peptide(VIP), by light chains purified from the IgG of a human subject .... Furthermore, VIP is recognized for its immunosuppressive properties and its potential role in certain disease states, often being upregulated in specific tumor types.
VIP antibodies are broadly categorized into monoclonal and polyclonal types, each offering distinct advantages for specific research applications.
* Monoclonal antibodies are derived from a single clone of B cells and thus recognize a single epitope on the VIP molecule. This specificity leads to high consistency and reduced cross-reactivity, making them ideal for applications requiring precise target identification, such as Western blotting (WB), immunohistochemistry (IHC), immunocytochemistry (ICC), and immunoprecipitation (IP).
* Polyclonal antibodies, on the other hand, are a mixture of antibodies produced by different B cell clones, recognizing multiple epitopes on the VIP peptideVasoactive intestinal polypeptide receptor 1 (VIP-R1) .... While they may offer broader recognition and potentially higher signal amplification, their batch-to-batch variability can be greater.Vasoactive Intestinal Peptide Antibody They are often used in ELISA and IHC, and some research has explored their use in detecting VIP in specific tissues like the rat amygdala, cortex, and suprachiasmatic nucleus, as well as ganglion cells in the small bowel.
The specificity of vasoactive intestinal peptide antibodies enables their use in a variety of experimental techniques to study VIP's function and distribution. Key applications include:
* Immunohistochemistry (IHC) and Immunocytochemistry (ICC): These techniques are vital for visualizing the localization of VIP within tissue sections and cells. VIP antibodies can reveal the presence of VIP in specific neuronal populations, such as ganglion cells in the gut, or in various brain regions like the amygdala and suprachiasmatic nucleus. This spatial information is critical for understanding VIP's role in signaling pathways and tissue functionVasoactive Intestinal Peptide (VIP) or PHM27 is encoded by the gene VIP and belongs to the glucagon family. VIP is a secreted peptide hormone and binds to the ....
* Western Blotting (WB): VIP antibodies are used to detect and quantify VIP protein levels in cell or tissue lysates. This is important for assessing changes in VIP expression under different physiological or pathological conditions.
* Enzyme-Linked Immunosorbent Assay (ELISA): ELISA assays employing VIP antibodies can accurately measure the concentration of VIP in biological fluids like serum or plasma, aiding in diagnostic or prognostic studies.
* Immunoprecipitation (IP): This method uses VIP antibodies to isolate VIP from a complex mixture, often for subsequent analysis of its binding partners or modificationsThisantibodydetects ganglion cells in both the superficial and deep plexus of the wall of the small bowel in human. The VIP producing tumors are usually ....
When selecting a vasoactive intestinal peptide antibody for your research, several factors warrant careful consideration to ensure optimal results. The antibody's target specificity is paramount; it should reliably bind to the VIP peptide and exhibit minimal cross-reactivity with other related peptides or proteins(20077) VIP (Vasoactive Intestinal Peptide) Antibody. Verification of species reactivity is also crucial, as antibodies validated for human samples may not perform equivalently in rodent or other mammalian tissues.
The antibody's performance in specific applications, such as IHC, WB, ICC, or ELISA, should be confirmed through the manufacturer's data or peer-reviewed literature. Dilution ranges and recommended protocols for staining procedures, particularly for IHC on frozen or paraffin-embedded sections, are important practical details. Furthermore, the clonality (monoclonal or polyclonal), format (e.gAnti-vasoactive intestinal peptide Antibody Products., purified IgG, serum, conjugated), and supplier reputation can influence experimental outcomes. Researchers often seek antibodies that have been cited in a substantial number of publications, indicating their established utility and reliability in the scientific communityIt stimulates myocardial contractility,causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, ....
Vasoactive intestinal peptide antibodies are available from several specialized suppliers catering to the life science research market.Vasoactive intestinal peptide monoclonal antibody (2) These suppliers offer a range of antibody formats, including rabbit polyclonal antibodies, rabbit monoclonal antibodies, and conjugated versions (eVasoactive intestinal polypeptide receptor 2 (VIP-R2) ....g., CoraLite Plus 488-conjugated VIP Polyclonal antibody) suitable for direct detection in fluorescence-based assays. When sourcing these antibodies, it is advisable to consult product datasheets for detailed technical specifications, validation data, and recommended storage and handling procedures, especially for sensitive reagents.
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