trail peptide TRAIL-R3 (CD263 - Retatrutidepeptide TRAIL-R3 (CD263

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TRAIL Peptide: A Key Player in Apoptosis and Cancer Research

The TRAIL peptide, also known as Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) or Apo2L, is a critical signaling molecule that plays a significant role in programmed cell death, or apoptosis.TRAIL-based gene delivery and therapeutic strategies This potent inducer of apoptosis preferentially targets cancer cells, making it a subject of intense research for potential cancer therapiesTRAIL-based gene delivery and therapeutic strategies. Understanding the function and applications of TRAIL peptide is essential for researchers and clinicians exploring novel strategies to combat various forms of cancer.

Understanding TRAIL Peptide and Its Mechanism

TRAIL is a cytokine belonging to the TNF superfamilyTRAIL/Apo2L, also known as Tumor Necrosis Factor Super-Family 10 (TNFSF10), is a pleiotropic cytokine thatbelongs to the TNF superfamily.. It exerts its function by binding to specific death receptors on the surface of target cells, primarily TRAIL-R1 and TRAIL-R2. This binding initiates a cascade of intracellular events that ultimately lead to apoptosis. Crucially, TRAIL demonstrates a remarkable selectivity, inducing apoptosis in a wide array of cancer cells while largely sparing normal, healthy cells. This selective cytotoxicity is a highly desirable characteristic for therapeutic agents.

Beyond its direct action, TRAIL peptide is also recognized for its use in laboratory settings. It can function as a blocking peptide, employed in neutralization and control experiments to study antibody interactions or to specifically inhibit TRAIL-mediated signaling. Furthermore, synthetic peptides that mimic TRAIL's structure are being developed as potential therapeutic agents themselves, aiming to harness the natural apoptotic pathways for cancer treatment作者：Y Kim·2003·被引用次数：108—TRAIL has been shown to be a potent apoptosis inducerin a wide variety of cancer cells in vitro and to limit tumor growth efficiently in vivo without damaging ....

TRAIL Peptide in Cancer Therapy Research

The selective induction of apoptosis in tumor cells by TRAIL peptide has positioned it as a promising candidate for cancer therapy. Researchers are actively investigating various approaches to leverage TRAIL's capabilities:

* Direct Therapeutic Use: While direct administration of TRAIL has faced challenges, such as short half-life and potential off-target effects, ongoing research focuses on developing more stable and effective TRAIL-based therapeutics, including recombinant TRAIL fusion proteins.Invitrogen Human CD253 (TRAIL) (aa 207-220) Synthetic ...

* Mimicking Peptides: The development of TRAIL-mimicking peptides offers an alternative strategy. These engineered peptides can effectively trigger the TRAIL death pathway, potentially leading to tumor regression.

* Gene Therapy: Gene transfer methods are also being explored, aiming to deliver the TRAIL gene or protein directly into cancer cells, thereby inducing apoptosis from within.

* Targeting TRAIL Receptors: Research also extends to understanding and modulating TRAIL receptors, such as TRAIL R3 (also known as CD263), which can act as an antagonist decoy receptor, inhibiting TRAIL-induced apoptosis. Manipulating these receptor interactions could offer further therapeutic avenuesTRAIL/Apo2L, also known as Tumor Necrosis Factor Super-Family 10 (TNFSF10), is a pleiotropic cytokine thatbelongs to the TNF superfamily..

Applications and Variations

TRAIL peptide and its related molecules serve diverse purposes in biological research:

* Research Reagents: TRAIL peptides are widely used as blocking peptides for antibodies, as well as in experiments designed to study apoptosis pathways and receptor interactions. Various recombinant human and mouse TRAIL proteins are available for research applications作者：P Gurung·2010·被引用次数：25—Abstract. Mechanism behind transient peripheral tolerance induced after T cell deletion is identified as dependent on the cytotoxic activity ofTRAIL-expre..

* Diagnostic and Investigative Tools: The ability of TRAIL to induce apoptosis makes it a valuable tool for understanding cancer biology and for developing diagnostic markers.

* Synthetic Analogs: Beyond full-length TRAIL, synthetic peptide fragments and analogs are synthesized for specific experimental needs or therapeutic development, such as the human CD253 (TRAIL) (aa 207-220) synthetic peptide.

The study of TRAIL peptide continues to evolve, with ongoing efforts to enhance its therapeutic efficacy and broaden its applications in cancer treatment and fundamental biological researchTRAIL R3 (Extracellular Domain – 1) Blocking Peptide. Its selective cytotoxic properties and central role in apoptosis make it a cornerstone molecule in the quest for more effective cancer therapies.作者：A Montinaro·2023·被引用次数：132—Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL)can induce apoptosis in a wide variety of cancer cells, both in vitro ...