NK2Rdrug name The neurokinin 2 receptor (NK2R) is a key player in regulating energy balance, with research increasingly focusing on its potential as a therapeutic target for metabolic diseases. As part of the broader neurokinin receptor family, NK2R is activated by neuropeptides like neurokinin A (NKA), a peptide that plays a crucial role in controlling appetite and energy expenditure. Understanding the intricate mechanisms of NK2R activation and signaling is paramount for developing novel treatments that can effectively manage conditions such as obesity.NK2R Small Molecules and Peptides. The Neurokinins, also known as Tachykinins, belong to an evolutionary conserved family of peptide neurotransmitters that ...
The neurokinin 2 receptor (NK2R), also known as TACR2, is a G protein-coupled receptor that preferentially binds to natural peptide ligands.NK2R Antibodies This receptor is a significant component of the neurokinin receptor family, which comprises three distinct members. NK2R is primarily activated by neurokinin A (NKA), a neuropeptide that influences various physiological processes. Research indicates that activation of NK2R can suppress appetite centrally and concurrently boost energy expenditure peripherally.作者：S Zoffmann·2007·被引用次数：13—When bound to aNK2Rcarrying enhanced green fluorescent protein at the N-terminus, allpeptidesreduce green fluorescent protein fluorescence from 10% to 50% ... This dual action makes NK2R a compelling target for interventions aimed at weight management and the treatment of metabolic disorders.
The therapeutic implications of targeting NK2R are becoming increasingly evident, particularly in the realm of obesity treatmentNK2R control of energy expenditure and feeding to ... - Nature. Selective NK2R peptide agonists have demonstrated the ability to increase energy expenditure, reduce fat mass, and suppress appetite in preclinical studies.2024年12月15日—Drugs targeting NK2Rmay also lead to significant weight lossfor people who do not achieve satisfactory weight loss with existing treatments. “ ... This suggests a promising avenue for developing new weight loss medications. Unlike some existing peptide-based drugs, NK2R agonists that are small molecules could offer a more cost-effective production pathway, potentially making them more accessible.Weight Loss Drug Curbs Appetite, Burns Energy, Skips ... Furthermore, drugs targeting NK2R may provide significant weight loss benefits for individuals who do not respond adequately to current treatments.
Despite the promising therapeutic potential, developing effective NK2R-based drugs faces certain challenges. The body's natural activator for NK2R, Neurokinin A (NKA), has a very short half-life, making it unsuitable for direct therapeutic useMolecular determinants of neuropeptide-mediated .... NKA is a linear peptide composed of 10 amino acids, and its rapid degradation in the body limits its efficacy as a drug.作者：J Haskell·2024—An agonist of the neurokinin 2 receptor induced weight loss and increased energy expenditure in obese mice and monkeys with diabetes. This limitation necessitates the development of more stable synthetic agonists or antagonists that can effectively modulate NK2R activity without the pharmacokinetic drawbacks of NKA. Researchers are exploring NK2R small molecules and peptides designed to overcome these issues, aiming for improved stability and therapeutic effectiveness.
Advancing the understanding and therapeutic application of NK2R relies on a range of research tools and reagents. These include various NK2R antibodies, which are crucial for detecting and quantifying the receptor in biological samples across different model species like bovine, human, and ratAnti-Neurokinin 2 Receptor (NK2R) Antibody (#ATR-002)is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used .... Blocking peptides, such as the Neurokinin 2 Receptor/NK2R Blocking Peptide, are also vital. These peptides bind to and inhibit NK2R antibodies, serving as essential negative controls to confirm the specificity of antibody-based detection methods. Additionally, cell lines engineered to express NK2R are valuable for high-throughput screening of potential drug candidates and for studying receptor signaling pathwaysNK2R Antibody - BSA Free (NBP3-14421). The development of selective NK2R agonists, like EB1002, which has been shown to enhance the expression of genes related to mitochondrial biogenesis and energy expenditure in obese mouse models, further underscores the importance of these research tools作者：F Sass·2024·被引用次数：34—Here we show that activation ofneurokinin 2 receptor (NK2R) is sufficient to suppress appetite centrally and increase energy expenditure peripherally..
Emerging research highlights the critical role of NK2R in maintaining energy balance and glucose control. Genetic screens have implicated NK2R in these fundamental physiological processes. Targeting NK2R has shown potential in reversing cardiometabolic dysfunction. For instance, studies in obese mice and monkeys with diabetes demonstrated that an agonist of the neurokinin 2 receptor induced weight loss and increased energy expenditure. This suggests that modulating NK2R activity could be a viable strategy for addressing complex metabolic conditions. The receptor's influence extends to intestinal lipid mobilization, further emphasizing its comprehensive role in metabolic regulation.
The ongoing research into NK2R signifies a burgeoning field with substantial potential for clinical impact.EB1002 是一种选择性NK2R 激动剂。EB1002 显著提高了肥胖小鼠线粒体生物合成相关基因(如PGC-1α) 的表达水平，表明其通过增强线粒体活动来促进能量消耗。 Future efforts are likely to focus on designing more potent and selective NK2R modulators, whether they are peptide-based or small molecule compoundsView 12 NK2R products. R&D Systems offers high-quality reagents, instruments, custom manufacturing and testing services.. Understanding the precise structural interactions between NK2R and its ligands, including NKA and synthetic compounds, is crucial for rational drug design.Topological analysis of the complex formed between ... Further investigation into the signaling pathways downstream of NK2R activation will also provide deeper insights into its physiological roles and therapeutic leverage. As research progresses, the development of effective NK2R-targeting therapies could offer new hope for treating obesity and related metabolic diseases, potentially providing a novel alternative to existing treatments.
Join the newsletter to receive news, updates, new products and freebies in your inbox.