ACPeptides
Anti-ACE peptides are short chains of amino acids that can inhibit the activity of angiotensin-converting enzyme (ACE).作者：NA Pearman·2025·被引用次数：6—Peptidesisolated from various biological materials are potential sources for novel angiotensin-converting enzyme (ACE) inhibitors. Here, theACE-inhibitory ... ACE plays a crucial role in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure.2天前—An extensive body of research has identifiedACE-inhibitorypeptidesfrom numerous food sources, including milk, fish, eggs, and plants; and ... By inhibiting ACE, these peptides can help lower blood pressure and may offer other health benefits. Research into ACE-inhibitory peptides is exploring various sources, from common food proteins to specialized biological materials, aiming to harness their potential for both therapeutic and functional food applications.作者：S Abachi·2019·被引用次数：120—ACEinhibitorypeptidesmust be absorbed from the intestine and reach the cardiovascular system in their original shape to hinder the activity ofACE[36].
A significant body of research focuses on identifying naturally occurring ACE-inhibitory peptides from diverse sources. These peptides are often derived from the hydrolysis of larger proteins found in various foods.
* Dairy Proteins: Milk proteins, particularly casein, are a well-studied source of ACE-inhibitory peptides. Casein-derived peptides have demonstrated the ability to reduce blood pressure in animal studies, with ongoing research investigating their efficacy in human trials作者：B Shao·2023·被引用次数：28—The main purpose of this study was to isolate and identify Angiotensin Converting Enzyme (ACE) inhibitorypeptides(IPs) from black soybean protein .... Goat milk whey and caseins, for instance, have yielded potent ACE-inhibitory peptides.
* Plant Proteins: Many plant-based proteins also serve as precursors for ACE-inhibitory peptides. Soy protein, mung bean proteins, and proteins from black soybeans have been explored, with studies identifying specific peptide sequences that exhibit significant ACE inhibition.
* Other Food Sources: Beyond dairy and legumes, a variety of other food products are being investigated. Fish proteins, eggs, and even by-products like rice wine lees can yield peptides with ACE-inhibitory activity. Red algae and insect-derived proteins are also emerging as potential sources作者：K Li·2025·被引用次数：9—Casein-derivedpeptideshave been shown to reduce blood pressure in animal studies, but evidence from human trials remains limited..
* Biological Materials: Beyond food, peptides isolated from various biological materials are being explored for their potential as novel ACE inhibitors作者：B Daza-Rodríguez·2023·被引用次数：9—Mostpeptidesdescribed in the literature with antihypertensive properties can inhibit angiotensin-I converting enzyme (ACE-I), a key regulator ....
ACE-inhibitory peptides exert their primary effect by blocking the action of the ACE enzyme. ACE is responsible for converting angiotensin I to angiotensin II, a potent vasoconstrictor that raises blood pressure. By inhibiting this conversion, ACE-inhibitory peptides help to relax blood vessels, thereby lowering blood pressure.
The effectiveness of these peptides depends on their ability to be absorbed from the intestine and reach the cardiovascular system intact. Research also indicates that these peptides can bind to the active sites of ACE, sometimes by chelating zinc atoms essential for enzyme activity.
Beyond their antihypertensive properties, some ACE-inhibitory peptides may also possess antioxidant and anti-inflammatory benefits, further contributing to overall health. The exploration of these peptides is considered a gentler and potentially safer alternative to traditional ACE inhibitor drugs for managing blood pressure.
The field of ACE-inhibitory peptides is dynamic, with ongoing research focusing on isolating, characterizing, and understanding the mechanisms of novel peptides. Key areas of investigation include:
* Identification of Potent Peptides: Researchers are continuously working to discover new peptides with higher ACE-inhibitory potency and stability.
* In Vitro and In Vivo Studies: While many studies demonstrate ACE inhibition in laboratory settings and animal models, more human trials are needed to confirm their therapeutic efficacy and safety.
* Functional Food Applications: The potential to incorporate ACE-inhibitory peptides into functional foods offers a way to naturally support cardiovascular health through dietary intake.
* Synergistic Effects: Investigating how different peptides or combinations of peptides might work together to enhance ACE inhibition is another area of interest.Top 9 Benefits of NAC (N-Acetyl Cysteine)
While the research is promising, it's important to distinguish these naturally derived peptides from pharmaceutical ACE inhibitors. The development of these peptides holds potential for both dietary supplements and novel therapeutic strategies for managing hypertension and related cardiovascular conditions.
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