Parathyroidhormone 中文 Human parathyroid peptide, primarily known as Parathyroid Hormone (PTH), is a crucial peptide hormone secreted by the parathyroid glands that plays a central role in regulating calcium and phosphate levels within the body. This vital hormone acts to elevate blood calcium by influencing bone resorption and reabsorption in the kidneys, while also impacting phosphate levels. Beyond the full-length PTH, various fragments and related peptides, such as PTH-related peptide (PTHrP), exhibit significant biological activity and are important in different physiological and pathological contextsOverview: Parathyroid Hormone-Related Peptide, Plasma. Understanding these human parathyroid peptides is key to comprehending calcium metabolism and related disorders.Parathyroid hormone-related protein
The main function of human parathyroid hormone (PTH) is to maintain calcium homeostasis. When blood calcium levels drop, the parathyroid glands release PTH. This hormone then acts on several target organs:
* Bone: PTH stimulates osteoclasts, leading to the breakdown of bone tissue.作者：J Höppner·2025·被引用次数：5—Parathyroidhormone (PTH) analogs with improved actions in vivo could lead to optimized treatments for bone and mineral ion diseases. This process releases stored calcium and phosphate into the bloodstream.
* Kidneys: PTH increases the reabsorption of calcium in the renal tubules, preventing its excretion in urine. It also inhibits the reabsorption of phosphate, thus lowering blood phosphate levels2023年5月12日—The parathyroid hormone-related protein (PTH-RP) testmeasures the level of a hormone in the blood, called parathyroid hormone-related protein.. Furthermore, PTH promotes the conversion of vitamin D to its active form, calcitriol, which enhances calcium absorption from the intestines.
* Intestines: Indirectly, through the activation of vitamin D in the kidneys, PTH increases the absorption of calcium from dietary sources in the small intestine.
While PTH is central to calcium regulation, the family of human parathyroid peptides also includes Parathyroid Hormone-Related Peptide (PTHrP)pTH (1-37) (human) is a fragment of parathyroid hormone (PTH). pTH (1-37) (human) induces the cAMP formation and increases alkaline phosphatase activity.. Unlike PTH, which is primarily produced by the parathyroid glands, PTHrP is widely expressed in numerous tissues and organs, including bone, cartilage, and even in some tumors.
PTHrP shares structural similarities with PTH and can bind to the same receptor (PTH1R). However, its physiological roles are distinct and multifaceted. PTHrP is involved in fetal development, regulating calcium transfer across the placenta, and plays roles in lactation, dental eruption, and skin development.Parathyroid hormone-related protein blood test - UCSF Health In certain cancers, tumors can overproduce PTHrP, leading to a condition known as humoral hypercalcemia of malignancy, where elevated blood calcium levels occur due to the peptide's actions mimicking PTH.
Other variations, such as specific fragments like PTH (1-34), which represents the biologically active amino-terminal portion of the full 84-amino acid hormone, are also significant. These fragments are often used in research and therapeutic applications due to their potent effects on calcium metabolism. For instance, PTH (1-34) is a well-studied peptide that can be administered to treat conditions like osteoporosis, promoting bone formation.
The study of human parathyroid peptides is vital for diagnosing and managing various endocrine and metabolic disorders. Conditions such as hyperparathyroidism (overactive parathyroid glands) and hypoparathyroidism (underactive parathyroid glands) are directly related to abnormal PTH levels. Similarly, the detection of elevated PTHrP levels can help diagnose and monitor certain types of cancer.
Research into these peptides also focuses on developing novel therapeutic agents. Analogs of PTH, such as teriparatide (a form of PTH (1-34)), are already used to treat osteoporosis by stimulating bone formation. Ongoing research aims to create PTH analogs with improved actions in vivo for more optimized treatments for bone and mineral ion diseases. The availability of high-purity synthetic peptides, including PTH (1-34) and PTH (1-44) human peptides, is essential for this research, enabling scientists to investigate their precise mechanisms of action and explore new therapeutic avenues.Parathyroid Hormone (PTH) (1-34), Human
In conclusion, human parathyroid peptide, in its various forms including PTH and PTHrP, is fundamental to calcium and phosphate regulation. Their intricate roles in bone metabolism, kidney function, and broader physiological processes underscore their importance in maintaining overall health, and their dysregulation can lead to significant clinical conditions.Product Specs; ItemHuman ParathyroidHormone-Related Protein / PTHrP (PTHLH)Peptide(OVA); CompanyAbbexa Ltd; Price 3.00Supplier PageView Company ...
Join the newsletter to receive news, updates, new products and freebies in your inbox.