PeptideSciences Human relaxin-2 (RLN2) is a fascinating 6 kDa polypeptide hormone, a key member of the relaxin peptide family, structurally akin to insulin. This peptide plays a crucial role in various physiological processes, particularly in female reproduction, and is increasingly recognized for its significant therapeutic potentialRLN2 is a peptide hormoneassociated with a number of therapeutically relevant physiological effects, including regulation of collagen metabolism and.. Understanding its structure, function, and applications is vital for researchers and clinicians alikeRelaxin-2 Products.
Human relaxin-2 is a heterodimeric protein, typically composed of a 24-amino acid A-chain and a 29-amino acid B-chain, linked by two disulfide bonds. The gene encoding human relaxin-2, RLN2, is located on human chromosome 9p24Relaxin-2 is a peptide hormonestructurally related to insulin, which is expressed in the placenta, decidua, prostate, and in the ovary during pregnancy.. While it's a 53-amino acid peptide in total, its structure is complex, with the A-chain and B-chain originating from a single prohormone. The precise three-dimensional structure, including the NMR structure of monomeric and amidated forms, has been a subject of intense scientific investigation, revealing intricate details about its folding and stability.
The primary recognition of relaxin-2 has been its role as an ovarian hormone, acting in concert with estrogen to facilitate birth canal dilation during mammalian pregnancy. It is expressed in several tissues, including the placenta, decidua, corpus luteum of the ovary, and even the prostate in humans. Beyond its reproductive functions, relaxin-2 is known to mediate a range of cardiovascular effects, including antifibrotic, angiogenic, and vasodilatory properties. Its influence extends to the regulation of collagen metabolism and connective tissue remodeling, highlighting its broad physiological impact.
The pleiotropic effects of human relaxin-2 have positioned it as a promising therapeutic agent2MV1: Solution NMR structure of Human Relaxin-2. Its antifibrotic and vasodilatory actions are particularly relevant for conditions like congestive heart failure, where it is currently undergoing clinical trials with commercial partners like BAS Medical. Furthermore, its ability to promote cervical ripening is being explored for obstetric applicationsRelaxin in paraventricular nucleus contributes to sympathetic overdrive and hypertensionvia PI3K-Akt pathway. · H2 and H3 relaxin inhibit high glucose-induced .... Research is also investigating its potential in treating conditions involving excessive collagen deposition or impaired vascular functionRelaxin 2 (Human) - 20µg. The development of recombinant human relaxin-2 has been critical in enabling these studies, providing a reliable source of the peptide for research and potential clinical usePeptide Institute, Inc. is aglobal supplier of Relaxin-2 (Human) from Japan. Name:Relaxin-2 (Human), Code:4509-v, Hormone of Pregnancy, also known as an ....
For research purposes, human relaxin-2 peptide is available from various global suppliers. These often offer recombinant forms, ensuring high purity (typically ≥98% by HPLC) for experimental use. When sourcing, details such as the protein's origin (eIdentification of Potent and Long-Acting Single-Chain Peptide ....g., human, recombinant), purity, molecular weight (around 6 kDa), and specific chain compositions (A-chain and B-chain lengths) are important considerations.
In conclusion, human relaxin-2 peptide is a multifaceted hormone with significant implications for both fundamental biology and clinical medicine. Its intricate structure underlies its diverse physiological functions, from reproductive processes to cardiovascular health. Ongoing research and clinical trials continue to unveil its full therapeutic potential, marking it as a molecule of considerable scientific and medical interestRLN2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol..
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